Post-translation modifications

Translation and post-translational modifications in Plasmodium

Malaria is one of the most important human parasitic diseases in the world, affecting about 400 million people and killing about 1 million children every year. Our relationship with the malarial parasite has been a long one on the evolutionary scale, and the methods adopted by the parasite to thrive and colonize our bodies are truly fascinating. In order to control the disease, it is of fundame...

Modifications on Translation Initiation

Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.

Editorial: Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications

Post-Translational Modifications of Cardiac Mitochondrial Proteins in Cardiovascular Disease: Not Lost in Translation

Protein post-translational modifications (PTMs) are crucial in regulating cellular biology by playing key roles in processes such as the rapid on and off switching of signaling network and the regulation of enzymatic activities without affecting gene expressions. PTMs lead to conformational changes in the tertiary structure of protein and resultant regulation of protein function such as activat...

Post-translational modifications of tubulin

Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...